Endocrine disruption in Crohn’s disease: Bisphenol A enhances systemic inflammatory response in patients with gut barrier translocation of dysbiotic microbiota products

The relevance of environmental triggers in Crohn's disease remains poorly explored, despite the well-known association between industrialization and onset/progression. We have aimed at evaluating influence endocrine disrupting chemicals CD patients. performed a prospective observational study on consecutive patients diagnosed CD. Serum levels disruptors, short-chain fatty acids, tryptophan cytokines were measured. Bacterial-DNA serum endotoxin also evaluated. Gene expression ER-?, ER-? GPER was measured PBMCs. All genotyped for NOD2 ATG16L1 polymorphisms. A series 200 (140 remission, 60 with active disease) included study. Bisphenol significantly higher versus remission colonic ileal disease. increased correlated BPA levels. bacterial-DNA levels, (r = 0.417; P .003). butyrate lower an inverse relationship present them ?0.491; .001) ?0.611; .001). IL-23 0.807; IL-17A 0.743; multivariate analysis revealed independent significant contribution to IL-17A. In conclusion, bisphenol affects systemic inflammatory response gut barrier disruption dysbiotic microbiota secretory products blood. These results provide evidence disruptor playing actual pathogenic role